Officers were called to the intersection of Castle Hill and Gleason avenues in the Parkchester section early Sunday morning.
Paramedics rushed the 22-year-old victim to the hospital, where he was declared dead.
No arrests have been made, and the investigation is ongoing.
The identity of the deceased is pending family notification.
Anyone with information in regards to this incident is asked to call Crime Stoppers at 1-800-577-TIPS (8477).