The collision happened at the intersection of Bedford and Clarkson avenues in Prospect Lefferts Gardens.
Investigators say the driver of an SUV hit a parked car, then struck three or four other vehicles before the driver fled the scene on foot. Police are still searching for him or her.
Two people were rushed to the hospital in serious condition. The five other injuries are considered minor.
Sources tell Eyewitness News there was alcohol in the abandoned vehicle.