EMS received a 911 call of the shooting at 4:16 a.m. Saturday on East 16th Street between Avenue I and Avenue J.
Both victims were found inside a car.
An eyewitness says she she heard several gunshots and then heard tires squeal as a car drove off.
A 23-year old man was shot in the head and pronounced dead at the scene by EMS.
The second victim, a 24-year old man, is in critical condition at Kings County Hospital.