The two-alarm fire is burning on all three floors, and has caused a partial collapse of the structure.
One firefighter has suffered minor injuries in the blaze.
The fire broke out at the Verona Avenue building around 4:45 p.m. Wednesday and quickly went to two alarms.
The building is near the intersection with Broadway.
Police have closed off the area around the fire on Broadway, between Mill and Irving Streets.
The cause of the fire is under investigation.