Wytia McColley, 8, and Qiarah Barmore, 14, were last seen at approximately 7:30 Saturday night on Gun Hill Road.
Barmore is described as 5'5" and 180 pounds, with brown eyes and black hair. She was last seen wearing a multi-colored baseball cap, a multi-colored shirt and blue jeans. McColley is 4'7" and weighs 80 pounds.
Anyone with information on the whereabouts of the two girls is asked to call the NYPD's Crime Stoppers Hotline at 800-577-TIPS.