It happened early Saturday morning on Fulton Street in Bedford-Stuyvesant.
Police released surveillance footage of the two suspects running from the scene.
They're accused of shooting and killing 17-year old Kamau Chandler.
Police say the victim and his friends were walking on the street when they were approached from behind by the two suspects.
After the two groups began arguing, police say one of the suspects pulled a gun and shot Chandler in the head and chest.
He was pronounced dead on arrival at Interfaith Hospital.
The suspects are described as a black male in his 20's, thin with short hair, wearing an orange shirt with a dark strip on it, and a black male, 6'2" tall wearing a navy blue cut off hoody.
Anyone with information is asked to call the NYPD's Crime Stoppers Hotline at 800-577-TIPS.