Police say 41-year-old Ricardo Medina-Baez, of Long Beach, is hospitalized after slamming into the home on Glen Cove Avenue and University Place in Glen Cove around 1 a.m.
The car then burst into flames, scorching the side of the home.
The extent of Medina-Baez' injuries wasn't immediately known.
An elderly woman who lived in the home was awakened by the crash, smelled the smoke and was able to escape without injury.
The vehicle was impounded.
Medina-Baez was charged with driving while intoxicated and will be arraigned as soon as medically practical.