The fire broke out at about 9:30 Sunday morning at a private house on 119-46th Street.
Firefighters were on the scene within minutes, but were unable to save the life of the victim, who was pronounced dead at the scene.
The person has not yet been identified.
The fire was confined to the first floor of the two story residence and was placed under control within a half hour.
60 firefighters and 12 pieces of fire apparatus responded to the scene.