The crash happened around 2 a.m. on Route 25 and Huber Place in St. James.
Police say the driver of the car, identified as 25-year-old Jamie Rodriguez, of Hauppauge, died instantly. His Jeep Grand Cherokee was travelling eastbound when he apparently crossed into the westbound lanes and hit the Mack truck.
The truck driver, 50-year-old James Mundy, was was transported to Stony Brook University Hospital with non-life-threatening injuries.
The investigation into the cause of the crash is ongoing. Detectives are asking anyone with information about this crash to call the Fourth Squad at 631-854-8444.
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