It was very windy at the time of the accident late Friday morning.
Three children and three adults were inside the vehicle at the time.
The driver and front seat passenger, both adults, were hurt.
Officials say they were alert and talking as they were taken to a hospital. They were reportedly in good condition.
A boy who lives nearby says he witnessed the accident.
"I saw a lot of people rush over, pull over. Then, I saw the ambulance come. My mom called the ambulance," Oscar Hines told ABC7 Chicago.
Village crews have removed the tree from the street at 16th and Wilmette Avenue.