The fire broke out inside the Christ's Love Mission Center on East 152nd Street just after 11:30 p.m.
Flames tore through the building, and smoke spread to two floors of apartments above. The siding on the building buckled from the heat.
The residents of the apartments were left temporarily homeless.
The cause has not yet been determined, and the investigation is ongoing.
No injuries were reported.
Get Eyewitness News Delivered