The victims are believed to work inside the Sun Chemical Corp plant at 390 Central Avenue in East Rutherford.
According to officials, carbon dust in the building's dust collection system sparked, causing a explosion and fire.
The two burned workers were taken to the hospital.
At least four other workers were treated for exposure at the scene.
Firefighters who put out the fire were also checked out at the scene.
The building did not sustain any structural damage.
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