The accident happened at 12:30 Saturday morning on 39th Avenue and 64th Street.
According to police, a Q53 bus was travelling westbound when it hit an eastbound van.
The driver of the van, a 47-year-old man, was killed. His name was not immediately released.
The 46-year-old bus driver was taken to Elmhurst Hospital in stable condition.
Three people on the bus declined medical treatment, police said.
Investigators said no criminality was suspected, but the investigation is continues.
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