The vehicles collided just south of the Cross County Parkway around 6:10 a.m.
The car became trapped under the trailer, which then caught fire.
The truck driver escaped the burning vehicle with minor injuries.
The driver of the car was trapped in the vehicle, and presumed killed in the crash and flames.
The northbound New York State Thruway was closed, with traffic diverted onto local roads.
The cause of the crash is under investigation.
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