It happened shortly before 3:00 a.m. on the southbound FDR Drive near the Houston Street exit.
Police say a 26-year-old man driving a 1996 Nissan Maxima was traveling northbound on the southbound lane of the FDR Drive, when he struck head-on a 2002 Dodge Caravan being driven by a 53-year-old man.
A 22-year-old woman driving a 2000 Mazda then crashed into the Dodge Caravan from behind.
Both the drivers of the Nissan Maxima and the Dodge Caravan were pronounced dead at the scene.
The driver of the Mazda and his passenger were both transported to Bellevue hospital where they are listed in stable condition.
The investigation is ongoing. No charges have been filed.
No names have been released.
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