Ackerman is one of Europe's most powerful bankers and is a key advisor in the European Union debt crisis to Germany's Chancellor Angela Merkel.
He has played an important role in the efforts to reduce Greece's debt.
Recently the bank's Munich offices had been searched by prosecutor's investigation suspicions that he and other former top executives gave false testimony in an ongoing civil suit.
It was not immediately clear if his role in managing the debt crisis, or some other grievance had triggered the delivery of the bomb. It was discovered by a mailroom x-ray machine and it did not explode.
In New York City 10,000 security officials who take part in the NYPD Shield program were advised by the police unit of the attempted attack at the German bank and reminded them to alert their mail rooms to proper procedures for handling suspicious packages.
There is extra security at the Deutsche Bank building in NYC because of the incident in Frankfurt.
Other banks in the city were notified of the incident by the NYPD.