The blaze broke out around 2 a.m.in the basement of a seven-story building on Thompson Street.
The flames shot up a shaft to the roof.
Firefighters battled the fire for more than an hour.
Ten firefighters and one resident were treated for minor injuries.
Fire marshals searching the burned out SoHo building Friday afternoon found 10 pounds of marijuana in one of the apartments.
44-year-old Jennifer Tzar who lives in the apartment was taken into custody and charged with criminal possession of marijuana.
The cause of the fire remains under investigation.