The accident killed the driver of a pickup truck that was struck when the tractor trailer crossed into westbound traffic on I -84.
The victim was identified as 55-year-old James Mann of Newburgh.
The driver of the FedEx truck is 50-year-old Marion Williams of Leetonia, Ohio.
FedEx Spokesman Jim McCluskey released a statement saying, "This was a tragic accident and our heartfelt condolences and prayers go out to the family of the victim. We are working closely with authorities in their investigation."
No charges have been filed as the investigation continues.
State Police are asking any witnesses to call the Montgomery barracks at 845-457-1388.