The vehicle was pursued northbound on Route 21 when it crashed between exits 12 and 13 just before 9:30 p.m. Wednesday.
One of the people in the crashed car was taken to St. Joseph's Hospital in Paterson with critical injuries. One police officer was also treated for minor injuries.
The crash caused traffic delays on northbound Route 21 for hours.
The chase started when Clifton police were investigating a possible abduction.