The robbers allegedly pushed their way into the store just before 3 a.m. Monday after the store had closed at midnight and threatened the manager with a silver handgun.
Police say the manager was forced to open the safe and then bound with plastic ties.
The robbers left after emptying the safe of more than $200,000 in cash. Police say the manager was able to free himself and called police.
White Plains officials did not say if there were any witnesses or if any security guards were on duty at the time of the robbery, described as one of the biggest heists in city history.